Controlled substances must be stored in a securely locked, substantially constructed cabinet in compliance with 21 CFR 1301.75.
For Schedule I and II controlled substances, a substantially constructed safe or steel cabinet that is anchored to a wall or the floor is recommended.
Thiafentanil, carfentanil, etorphine hydrochloride and diprenorphine must stored in a safe or steel cabinet equivalent to a U.S. Government Class V security container.
Controlled substances requiring refrigeration must be locked in a container securely fastened within a refrigeration unit unless the refrigeration unit can be locked from the outside.
Keys allowing access to controlled substances must remain in the possession of the authorized users and not stored unsecured in the laboratory.
The room where the cabinet or safe is located should remained locked whenever the room is unoccupied.